Clik here to view.
Testing for CML
During your diagnosis and the early stages of your TKI therapy, some sort of genetic testing will be done regularly to search for the Philadelphia chromosome and/or the BCR-ABL1 gene. The following...
View ArticleAbout the qRT-PCR test
What the Quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR) test measures and its relationship to other testsThis section provides an overview of the quantitative Reverse...
View ArticleClik here to view.
The BCR-ABL1 gene and its messenger RNA, the Protein Tyrosine Kinase Bcr-Abl1
Chromosomes are found in a cell’s nucleus and are made up of tightly wound stretches of DNA, the genetic code essential for the life of the cell and therefore the life of the individual.The nucleus is...
View ArticleHow Q-PCR testing works in practice
We've explained how Q-PCR testing works and why it is important but how does it actually work in practise?Q-PCR testing extracts the available mRNA in a blood or marrow sample. A test result is...
View ArticleTesting response to treatment
Currently q-PCR is the most accurate test used to monitor your response to a particular therapy and to detect any significant rise in BCR-ABL1 transcripts. The test results are used to make...
View ArticleClik here to view.
About the Philadelphia Chromosome
The Philadelphia chromosome is an acquired abnormality and is the definitive marker for CML.It is formed when chromosomes 9 and 22 swop one part each with the other. It is not yet understood why this...
View ArticleNormal blood counts
An individual who has been diagnosed with CML should have routine blood tests, including a Complete Blood Count (CBC), blood differential and liver function tests (LFTs ), done on a regular basis to...
View ArticleClik here to view.
International standardisation (I.S.) of test results
The q-PCR Standardisation Project is designed to address the inconsistencies of q-PCR results reported between labs in different regions and countries.Professor Tim Hughes and his colleagues,...
View ArticleThe 10 most important things to remember about CML Testing
It's easy to become overwhelmed with the amount of technical information about blood testing which we need to learn to gain the most benefit from the results. Fact 1Your oncologist or haematologist is...
View ArticleThe future of CML Testing
New and Advanced Monitoring: q-PCR techniques; can we do even better?At the moment probably not, but in the future we should expect some changes. The recently published updated ELNet Recommendations...
View ArticleClik here to view.
Testing for CML
During your diagnosis and the early stages of your TKI therapy, some sort of genetic testing will be done regularly to search for the Philadelphia chromosome and/or the BCR-ABL1 gene. The following...
View ArticleAbout the qRT-PCR test
What the Quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR) test measures and its relationship to other testsThis section provides an overview of the quantitative Reverse...
View ArticleClik here to view.
The BCR-ABL1 gene and its messenger RNA, the Protein Tyrosine Kinase Bcr-Abl1
Chromosomes are found in a cell’s nucleus and are made up of tightly wound stretches of DNA, the genetic code essential for the life of the cell and therefore the life of the individual.The nucleus is...
View ArticleHow Q-PCR testing works in practice
We've explained how Q-PCR testing works and why it is important but how does it actually work in practise?Q-PCR testing extracts the available mRNA in a blood or marrow sample. A test result is...
View ArticleTesting response to treatment
Currently q-PCR is the most accurate test used to monitor your response to a particular therapy and to detect any significant rise in BCR-ABL1 transcripts. The test results are used to make...
View ArticleClik here to view.
About the Philadelphia Chromosome
The Philadelphia chromosome is an acquired abnormality and is the definitive marker for CML.It is formed when chromosomes 9 and 22 swop one part each with the other. It is not yet understood why this...
View ArticleNormal blood counts
An individual who has been diagnosed with CML should have routine blood tests, including a Complete Blood Count (CBC), blood differential and liver function tests (LFTs ), done on a regular basis to...
View ArticleClik here to view.
International standardisation (I.S.) of test results
The q-PCR Standardisation Project is designed to address the inconsistencies of q-PCR results reported between labs in different regions and countries.Professor Tim Hughes and his colleagues,...
View ArticleThe 10 most important things to remember about CML Testing
It's easy to become overwhelmed with the amount of technical information about blood testing which we need to learn to gain the most benefit from the results. Fact 1Your oncologist or haematologist is...
View ArticleThe future of CML Testing
New and Advanced Monitoring: q-PCR techniques; can we do even better?At the moment probably not, but in the future we should expect some changes. The recently published updated ELNet Recommendations...
View Article
